Development of an Unbiased Validation Protocol to Assess the Biofidelity of Finite Element Head Models used in Prediction of Traumatic Brain Injury

Authors: Chiara Giordano and Svein Kleiven—Royal Institute of Technology KTH, School of Technology and Health, Department of Neuronic Engineering

Abstract

This study describes a method to identify laboratory test procedures and impact response requirements suitable for assessing the biofidelity of finite element head models used in prediction of traumatic brain injury. The selection of the experimental data and the response requirements were result of a critical evaluation based on the accuracy, reproducibility and relevance of the available experimental data. A weighted averaging procedure was chosen in order to consider different contributions from the various test conditions and target measurements based on experimental error. According to the quality criteria, 40 experimental cases were selected to be a representative dataset for validation. Based on the evaluation of response curves from four head finite element models, CORA was chosen as a quantitative method to compare the predicted time history response to the measured data. Optimization of the CORA global settings led to the recommendation of performing curve comparison on a fixed time interval of 0-30 ms for intracranial pressure and at least 0-40 ms for brain motion and deformation. The allowable maximum time shift was adjusted depending on the shape of the experimental curves (D_MAX = 0.12 for intracranial pressure, D_MAX = 0.40 for brain motion and D_MAX = 0.25 for brain deformation). Finally, bigger penalization of ratings was assigned to curves with fundamentally incorrect shape compared to those having inaccuracies in amplitude or time shift (cubic vs linear). This rigorous approach is necessary to ensure confidence in the model results and progress in the usage of finite element head models for traumatic brain injury prediction.

Type: Full Paper

Keywords: Model validation, finite element (FE) head model, traumatic brain injury (TBI), biofidelity

© Stapp Association, 2016

Access Additional Papers from This Volume

View additional Full Papers from the Stapp Car Crash Journal, Volume 60.

• Age-Specific Injury Risk Curves for Distributed, Anterior Thoracic Loading of Various Sizes of Adults Based on Sternal Deflections
  Authors: Harold J. Mertz—General Motors Corporation (retired); Priya Prasad—Prasad Engineering, LLC; Dainius J. Dalmotas—D. J. Dalmotas Consulting, Inc.; Annette L….
• Association of Impact Velocity with Risks of Serious Injuries and Fatalities to Pedestrians in Commercial Truck-Pedestrian Accidents
  Authors: Yasuhiro Matsui and Shoko Oikawa—National Traffic Safety and Environment Laboratory, Japan; Kazuhiro Sorimachi, Akira Imanishi, and Takeshi Fujimura—Isuzu Advanced…
• Biomechanical Response of Military Booted and Unbooted Foot-Ankle-Tibia from Vertical Loading
  Authors: Frank A. Pintar, Michael B. Schlick, and Narayan Yoganandan—Medical College of Wisconsin and VA Medical Center; Liming Voo and…
• Biomechanical Responses of PMHS Subjected to Abdominal Seatbelt Loading
  Authors: Rakshit Ramachandra, Yun-Seok Kang, and John H. Bolte—The Ohio State University; Alena Hagedorn and Rodney Herriott—Transportation Research Center Inc.;…
• Development and Full Body Validation of a 5th Percentile Female Finite Element Model
  Authors: Matthew L. Davis, Bharath Koya, Jeremy M. Schap, and F. Scott Gayzik—Wake Forest School of Medicine, Virginia Tech-Wake Forest…
• Development of an Unbiased Validation Protocol to Assess the Biofidelity of Finite Element Head Models used in Prediction of Traumatic Brain Injury
  Authors: Chiara Giordano and Svein Kleiven—Royal Institute of Technology KTH, School of Technology and Health, Department of Neuronic Engineering Abstract This…
• Development, Evaluation, and Sensitivity Analysis of Parametric Finite Element Whole-Body Human Models in Side Impacts
  Authors: Eunjoo Hwang, Jingwen Hu, Cong Chen, Katelyn F. Klein, Carl S. Miller, and Matthew P. Reed—University of Michigan Transportation…
• Effect of Abdominal Loading Location on Liver Motion: Experimental Assessment using Ultrafast Ultrasound Imaging and Simulation with a Human Body Model
  Authors: Anicet Le Ruyet and Philippe Beillas—Univ Lyon, Université Claude Bernard Lyon 1, IFSTTAR, LBMC UMR_T9406, F69622, Lyon, France; Fabien…
• Evaluation of WIAMan Technology Demonstrator Biofidelity Relative to Sub-Injurious PMHS Response in Simulated Under-body Blast Events
  Authors: Hollie A. Pietsch, Kelly E. Bosch, and David R. Weyland—US Army Tank Automotive Research, Development, and Engineering Center; E….
• Investigation of Pelvic Injuries on Eighteen Post Mortem Human Subjects Submitted to Oblique Lateral Impacts
  Authors: Matthieu Lebarbé, Pascal Baudrit, and Pascal Potier—CEESAR; Philippe Petit, and Xavier Trosseille—LAB PSA Peugeot Citroën Renault; Sabine Compigne—Toyota Motor…
• Morphomics of the Talus
  Authors: David Gorman and Ebram Handy—General Motors LLC and International Center for Automotive Medicine Fellows; Sikui Wang and Annette L….
• New Risk Curves for NHTSA’s Brain Injury Criterion (BrIC): Derivations and Assessments
  Authors: Tony R. Laituri, Scott Henry, Kevin Pline, Guosong Li, Michael Frankstein, and Para Weerappuli—Ford Motor Company Abstract The National…
• Responses and Injuries to PMHS in Side-Facing and Oblique Seats in Horizontal Longitudinal Sled Tests per FAA Emergency Landing Conditions
  Authors: John R. Humm, Narayan Yoganandan, and Frank A. Pintar—Department of Neurosurgery, Medical College of Wisconsin; Richard L. DeWeese, David…
• The Effect of Rib Shape on Stiffness
  Authors: Sven A. Holcombe— Department of Biomedical Engineering/International Center for Automotive Medicine, University of Michigan; Stewart C. Wang—International Center for…
• The Large Omnidirectional Child (LODC) ATD: Biofidelity Comparison with the Hybrid III 10 Year Old
  Authors: Jason Stammen and Kevin Moorhouse—National Highway Traffic Safety Administration; Brian Suntay—Transportation Research Center Inc.; Michael Carlson and Yun-Seok Kang—The…
• Thoracic Injury Risk Curves for Rib Deflections of the SID-IIs Build Level D
  Authors: Annette L. Irwin, Greg Crawford, David Gorman, and Sikui Wang—General Motors LLC; Harold J. Mertz—General Motors Corporation (retired) Abstract…
• Traffic Accidents Involving Cyclists Identifying Causal Factors Using Questionnaire Survey, Traffic Accident Data, and Real-World Observation
  Authors: Shoko Oikawa and Yasuhiro Matsui—National Traffic Safety and Environment Laboratory, Japan; Toshiya Hirose—Shibaura Institute of Technology, Japan; Shigeru Aomura—Tokyo…

Looking for Something Else?